Amoxil is a broad-spectrum antibiotic. It belongs to the class of classical antibacterial agents and is still actively prescribed for treating a variety of diseases for both children and adults. The drug has a number of contraindications to admission. We can say that Amoxil is one of the most popular antibacterial drugs in the people.
The main active substance of the drug is amoxicillin trihydrate. Excipients are sodium carboxymethyl starch, magnesium stearate, talc, hypromellose.
The indicator of bioavailability is not related to food intake. The patient can take Amoxil tablets at any convenient time, and this will not affect the assimilation in any way.
Within two hours the drug is absorbed into the intestine. Three hours after ingestion, a consistently high concentration of the active substance is observed in the blood. In the lower sections of the gastrointestinal tract, the concentration is low, because of this the drug is not prescribed for the treatment of intestinal infections.
The active substance amoxicillin trihydrate is almost completely destroyed by the action of bacterial enzymes of beta-lactamases. Therefore, it makes no sense to prescribe it for the treatment of diseases provoked by beta-lactamase-producing strains.
You can buy the drug in capsules and tablets with an active substance concentration of 125, 250, 500 mg and 1000 mg. The powder is also available for making the suspension. The form of release does not affect the bioavailability.
The active substance of the drug perfectly overcomes the histohematological barrier, quickly and effectively creates therapeutic concentrations.
The most effective in diseases of the infectious nature of the following body systems: urinary system; gastrointestinal tract (with the exception of the lower intestine); skin problems, dermatitis, furunculosis; upper respiratory tract (angina, acute otitis media, pharyngitis, acute and chronic bronchitis, bronchopneumonia, lung abscess).
The drug is often prescribed for the treatment of various forms of gonorrhea, salmonella, Lyme disease.
Allergic reactions are possible: angioedema; anaphylactic shock; urticaria and various dermatitis; itching; rhinitis and conjunctivitis, tearing.
With prolonged use in doses over 1 g per day: asthenia, weakness; dizziness, loss of consciousness; drowsiness; inadequate actions.
In case of a simultaneous reception with preparations of clavulanic acid: cholestatic jaundice; toxic hepatitis (with prolonged admission); exfoliative dermatitis; toxic necrolysis.
The initial dosage of Amoxil for adults should not exceed 1500 mg (three tablets of 500 mg) per day. In severe disease, the daily dose can be increased to two grams of the drug because Amoxil can become more toxic to the patient.
In case of infectious and inflammatory diseases of the gastrointestinal tract, it is recommended to take from one to two grams per day. The duration of therapy depends on the severity of the symptoms and the health of the patients.
For children and adolescents, Amoxil is recommended as a suspension or syrup. Pharmacists do not advise giving capsules and pills to babies under seven years of age because of too high a concentration of active ingredient.
For children from three to seven years, it is not desirable to take more than 600 mg of medication per day. This amount of the drug can provoke side effects and allergic reactions.
This antibiotic freely penetrates through the placental barrier. After a couple of days of intake, it already accumulates in the tissues of the embryo. Due to this effect on the fetus, Amoxil is prescribed to pregnant women only in extreme cases.
If you have the following diseases, you should refrain from taking this medication: lymphocytic leukemia; respiratory viral infections; hypersensitivity to penicillins; bronchial asthma.
With hepatic insufficiency, cirrhotic condition and other chronic liver diseases, joint administration of Amoxil with clavulanic acid is prohibited. The admission of Amoxil for problems with the liver is possible only after the appointment of a doctor.
The drug is not allowed for chronic kidney failure.